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Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy

Overview of attention for article published in Lipids in Health and Disease, January 2009
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Title
Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy
Published in
Lipids in Health and Disease, January 2009
DOI 10.1186/1476-511x-8-54
Pubmed ID
Authors

David E Scheim

Abstract

Unsaturated fatty acids (UFAs) exhibit in vitro cytotoxicity against many malignant cell lines and yield decreased cancer incidence and reduced tumor growth in animal models. But clinical and animal studies to date have achieved response using only localized delivery methods such as intratumoral infusion. To explore possibilities for enhanced clinical efficacy, fresh surgical explants of tumors from 22 patients with five malignancies were exposed to gamma-linolenic acid (GLA) and alpha-linolenic acid (ALA) and analyzed with an in vitro chemosensitivity testing system, the Fluorescent Cytoprint Assay (FCA). A total of 282 micro-organ cultures derived from these malignant tumors were exposed to GLA and ALA at different concentrations.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 6%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Ph. D. Student 5 15%
Student > Bachelor 4 12%
Student > Postgraduate 3 9%
Student > Master 2 6%
Other 6 18%
Unknown 5 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 35%
Medicine and Dentistry 6 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Chemistry 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 1 3%
Unknown 10 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#3,886,588
of 4,771,370 outputs
Outputs from Lipids in Health and Disease
#441
of 520 outputs
Outputs of similar age
#127,545
of 159,939 outputs
Outputs of similar age from Lipids in Health and Disease
#18
of 21 outputs
Altmetric has tracked 4,771,370 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 520 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,939 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.