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EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats

Overview of attention for article published in Behavioral and Brain Functions, December 2017
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Title
EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats
Published in
Behavioral and Brain Functions, December 2017
DOI 10.1186/s12993-017-0132-5
Pubmed ID
Authors

Arvind Palanisamy, Gregory Crosby, Deborah J. Culley

Abstract

Our previous research showed that 4 h of maternal anesthesia with isoflurane during early gestation in pregnant rats leads to a deficit in spatial memory of adult male offspring. Because spatial memory is predominantly a hippocampally-mediated task, we asked the question if early gestational exposure to isoflurane affects development of the hippocampus in the offspring. Previously behaviorally characterized adult male rats that were exposed to isoflurane during second trimester were sacrificed at 4 months of age (N = 10 and 13, control and isoflurane groups, respectively) for quantitative histology of hippocampal subregions. Sections were stained with cresyl violet and the total number of cells in the granular layer of the dentate gyrus and the pyramidal cell layer in the CA1 region were determined by a blinded observer using unbiased stereological principles and the optical fractionator method. Data were analyzed using Student's t test; P < 0.05 was accorded statistical significance. Stereological examination revealed 9% fewer cells in the granular layer of the dentate gyrus of isoflurane-exposed adult rats compared to controls (1,002,122 ± 84,870 vs. 1,091,829 ± 65,791, respectively; Mean ± S.D, *P = 0.01). In contrast, there were no changes in the cell number in the CA1 region, nor were there changes in the volumes of both regions. Our results show that maternal isoflurane anesthesia in rodents causes region-specific cell loss in the hippocampus of adult male offspring. These changes may, in part, account for the behavioral deficits reported in adult rats exposed to isoflurane in utero.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 18%
Lecturer 2 12%
Unspecified 1 6%
Professor 1 6%
Other 1 6%
Other 2 12%
Unknown 7 41%
Readers by discipline Count As %
Medicine and Dentistry 3 18%
Neuroscience 2 12%
Unspecified 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 10 59%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2017.
All research outputs
#18,579,736
of 23,012,811 outputs
Outputs from Behavioral and Brain Functions
#288
of 391 outputs
Outputs of similar age
#329,847
of 441,813 outputs
Outputs of similar age from Behavioral and Brain Functions
#2
of 3 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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