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Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells

Overview of attention for article published in Journal of Nanobiotechnology, January 2008
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Title
Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells
Published in
Journal of Nanobiotechnology, January 2008
DOI 10.1186/1477-3155-6-2
Pubmed ID
Authors

Christopher J Gannon, Chitta Ranjan Patra, Resham Bhattacharya, Priyabrata Mukherjee, Steven A Curley

Abstract

Novel approaches to treat human cancer that are effective with minimal toxicity profiles are needed. We evaluated gold nanoparticles (GNPs) in human hepatocellular and pancreatic cancer cells to determine: 1) absence of intrinsic cytotoxicity of the GNPs and 2) external radiofrequency (RF) field-induced heating of intracellular GNPs to produce thermal destruction of malignant cells. GNPs (5 nm diameter) were added to 2 human cancer cell lines (Panc-1, Hep3B). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and propidium iodide-fluorescence associated cell sorting (PI-FACS) assessed cell proliferation and GNP-related cytotoxicity. Other GNP-treated cells were exposed to a 13.56 MHz RF field for 1, 2, or 5 minutes, and then incubated for 24 hours. PI-FACS measured RF-induced cytotoxicity.

Mendeley readers

The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 1%
United States 2 <1%
India 1 <1%
Germany 1 <1%
Iran, Islamic Republic of 1 <1%
Ukraine 1 <1%
Belgium 1 <1%
Poland 1 <1%
Unknown 207 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 64 29%
Researcher 41 19%
Student > Master 20 9%
Student > Bachelor 18 8%
Professor > Associate Professor 17 8%
Other 34 16%
Unknown 24 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 54 25%
Chemistry 31 14%
Engineering 23 11%
Medicine and Dentistry 20 9%
Biochemistry, Genetics and Molecular Biology 15 7%
Other 45 21%
Unknown 30 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#3,886,584
of 4,771,370 outputs
Outputs from Journal of Nanobiotechnology
#126
of 154 outputs
Outputs of similar age
#127,543
of 159,939 outputs
Outputs of similar age from Journal of Nanobiotechnology
#4
of 4 outputs
Altmetric has tracked 4,771,370 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 154 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,939 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.