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Anti-inflammatory T-cell shift in neuropathic pain

Overview of attention for article published in Journal of Neuroinflammation, January 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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6 tweeters
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1 Facebook page

Citations

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43 Dimensions

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96 Mendeley
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Title
Anti-inflammatory T-cell shift in neuropathic pain
Published in
Journal of Neuroinflammation, January 2015
DOI 10.1186/s12974-014-0225-0
Pubmed ID
Authors

Benjamin Luchting, Banafscheh Rachinger-Adam, Jens Heyn, Ludwig Hinske, Simone Kreth, Shahnaz Azad

Abstract

BackgroundThe classification of pain into nociceptive and neuropathic pain is based on characteristic symptoms and different pathophysiological mechanisms. In a recent investigation, we found a disrupted TH17/Treg balance in patients suffering from chronic unspecific low back pain (CLBP). These patients did not show any signs of neuropathy. There is evidence for a considerable impact of the immune system also in neuropathic pain. However, the role of the adaptive immune system is still unclear. In the present study, we investigated systemic T-cell subset responses and T-cell related cytokine profiles in patients with chronic neuropathic pain.MethodsWe analyzed T-cell subsets, mRNA expression and T-cell-related cytokine profiles in 26 patients suffering from neuropathic pain in comparison to 26 healthy controls. Using multicolor flow cytometry (FACS), we quantified the number of T helper cells 1 (TH1), TH2, TH17 and regulatory T-cells (Tregs). Forkhead-Box-Protein 3 (FoxP3), Transforming growth factor-ß (TGF-ß) and RAR-related orphan receptor-¿T (ROR-¿T) mRNA expression was determined by quantitative real-time PCR (qPCR) and levels of pain-related cytokines were measured by Human Cytokine Multiplex Immunoassay (Macrophage inflammatory protein-1¿ (MIP-1¿), Tumor necrosis factor-¿ (TNF-¿), Interferon-¿ (IFN-¿), Interleukin (IL) -4, IL-6, IL-10, IL-17, and IL-23).ResultsWe found a TH17/Treg imbalance with significantly increased anti-inflammatory Tregs and decreased pro-inflammatory TH17 cells in patients with neuropathic pain as compared to healthy controls. These results were confirmed on mRNA level: Treg-related FoxP3 and TGF-ß mRNA expression was elevated, whereas expression of TH17-related ROR¿T was reduced. Cytokine analyses revealed only marginal changes.ConclusionsOur investigation revealed a clear shift of T-cell subsets towards anti-inflammation in patients with neuropathic pain. Interestingly, this is quite similar to our previous findings in CLBP patients, but even more pronounced. Therefore, it remains to be elucidated in future investigations whether the immune changes represent an underlying pathophysiological mechanism or an epiphenomenon induced by ongoing pain and stress.German Clinical Trial Register (DRKS)Trial registration number: DRKS00005954.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Chile 1 1%
France 1 1%
Brazil 1 1%
Unknown 92 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 17%
Student > Ph. D. Student 14 15%
Student > Master 14 15%
Student > Doctoral Student 10 10%
Other 10 10%
Other 17 18%
Unknown 15 16%
Readers by discipline Count As %
Neuroscience 19 20%
Medicine and Dentistry 18 19%
Agricultural and Biological Sciences 13 14%
Biochemistry, Genetics and Molecular Biology 9 9%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Other 13 14%
Unknown 18 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2020.
All research outputs
#6,855,430
of 21,148,463 outputs
Outputs from Journal of Neuroinflammation
#1,106
of 2,439 outputs
Outputs of similar age
#97,720
of 320,718 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 9 outputs
Altmetric has tracked 21,148,463 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,439 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them