Title |
Human neural stem cell transplantation in ALS: initial results from a phase I trial
|
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Published in |
Journal of Translational Medicine, January 2015
|
DOI | 10.1186/s12967-014-0371-2 |
Pubmed ID | |
Authors |
Letizia Mazzini, Maurizio Gelati, Daniela Profico, Giada Sgaravizzi, Massimo Projetti Pensi, Gianmarco Muzi, Claudia Ricciolini, Laura Rota Nodari, Sandro Carletti, Cesare Giorgi, Cristina Spera, Frondizi Domenico, Enrica Bersano, Francesco Petruzzelli, Carlo Cisari, Annamaria Maglione, Maria Sarnelli, Alessandro Stecco, Giorgia Querin, Stefano Masiero, Roberto Cantello, Daniela Ferrari, Cristina Zalfa, Elena Binda, Alberto Visioli, Domenico Trombetta, Antonio Novelli, Barbara Torres, Laura Bernardini, Alessandro Carriero, Paolo Prandi, Serena Servo, Annalisa Cerino, Valentina Cima, Alessandra Gaiani, Nicola Nasuelli, Maurilio Massara, Jonathan Glass, Gianni Sorarù, Nicholas M Boulis, Angelo L Vescovi |
Abstract |
We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and neurosurgical procedures in these patients. The trial was approved by the Istituto Superiore di Sanità and the competent Ethics Committees and was monitored by an external Safety Board. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 2 | 25% |
Germany | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Scientists | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | <1% |
Italy | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 209 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 18% |
Student > Master | 30 | 14% |
Student > Bachelor | 29 | 14% |
Researcher | 28 | 13% |
Other | 9 | 4% |
Other | 28 | 13% |
Unknown | 52 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 14% |
Biochemistry, Genetics and Molecular Biology | 30 | 14% |
Neuroscience | 29 | 14% |
Agricultural and Biological Sciences | 27 | 13% |
Nursing and Health Professions | 8 | 4% |
Other | 29 | 14% |
Unknown | 60 | 28% |