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Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage

Overview of attention for article published in BMC Complementary Medicine and Therapies, January 2015
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Title
Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage
Published in
BMC Complementary Medicine and Therapies, January 2015
DOI 10.1186/s12906-015-0520-z
Pubmed ID
Authors

Shiow-Yunn Sheu, Shin-Rong Ho, Jui-Sheng Sun, Ching-Yun Chen, Cherng-Jyh Ke

Abstract

BackgroundIn osteoarthritis (OA), the imbalance of chondrocytes¿ anabolic and catabolic factors can induce cartilage destruction. Interleukin-1 beta (IL-1ß) is a potent pro-inflammatory cytokine that is capable of inducing chondrocytes and synovial cells to synthesize MMPs. The hypoxia-inducible factor-2alpha (HIF-2alpha, encoded by Epas1) is the catabolic transcription factor in the osteoarthritic process. The purpose of this study is to validate the effects of ecdysteroids (Ecd) on IL-1ß- induced cartilage catabolism and the possible role of Ecd in treatment or prevention of early OA.MethodsChondrocytes and articular cartilage was harvested from newborn ICR mice. Ecd effect on chondrocytes viability was tested and the optimal concentration was determined by MTT assay. The effect of HIF-2¿ (EPAS1) in cartilage catabolism simulated by IL-1ß (5 ng/ml) was evaluated by articular cartilage explants culture. The effects of Ecd on IL-1ß-induced inflammatory conditions and their related catabolic genes expression were analyzed.ResultsInterleukin-1ß (IL-1ß) treatment on primary mouse articular cartilage explants enhanced their Epas1, matrix metalloproteinases (MMP-3, MMP-13) and ADAMTS-5 genes expression and down-regulated collagen type II (Col2a1) gene expression. With the pre-treatment of 10¿8M Ecd, the catabolic effects of IL-1ß on articular cartilage were scavenged.ConclusionIn conclusions, Ecd can reduce the IL-1ß-induced inflammatory effect of the cartilage. Ecd may suppress IL-1ß- induced cartilage catabolism via HIF-2¿ pathway.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 17%
Researcher 3 17%
Student > Bachelor 3 17%
Student > Master 3 17%
Lecturer 1 6%
Other 1 6%
Unknown 4 22%
Readers by discipline Count As %
Immunology and Microbiology 3 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Biochemistry, Genetics and Molecular Biology 2 11%
Agricultural and Biological Sciences 2 11%
Medicine and Dentistry 2 11%
Other 2 11%
Unknown 5 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2015.
All research outputs
#20,010,843
of 22,489,892 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,710
of 3,303 outputs
Outputs of similar age
#274,628
of 326,939 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#1
of 1 outputs
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