Title |
MAGE-specific T cells detected directly ex-vivo correlate with complete remission in metastatic breast cancer patients after sequential immune-endocrine therapy
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Published in |
Journal for Immunotherapy of Cancer, September 2014
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DOI | 10.1186/s40425-014-0032-2 |
Pubmed ID | |
Authors |
Maxwell Janosky, Rachel L Sabado, Crystal Cruz, Isabelita Vengco, Farah Hasan, Arthur Winer, Linda Moy, Sylvia Adams |
Abstract |
Studies suggest that conventional cancer therapies given after immunotherapy (IT) can boost antitumor immunity and possibly improve response rates and progression-free survival. We report two cases of metastatic breast cancer with durable complete responses (CRs) after sequential IT and endocrine therapy. Immune analyses of these long-term disease-free breast cancer patients previously treated with imiquimod (IMQ) suggest in-situ vaccination is achieved by topical application of the TLR-7 agonist directly onto tumors. Furthermore, IT-induced antigen-specific T cells were expanded by subsequent endocrine therapy and correlated with response, persisting > 2 years. Our findings therefore suggest that the induction/boosting of polyfunctional tumor antigen-specific T in response to sequential immune endocrine therapy and detected directly ex-vivo can serve as a peripheral blood biomarker for true clinical benefit. |
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Demographic breakdown
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Unknown | 5 | 36% |