Title |
No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes
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Published in |
BMC Genomics, January 2018
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DOI | 10.1186/s12864-017-4412-0 |
Pubmed ID | |
Authors |
Ioannis D. Papadimitriou, Sarah J. Lockey, Sarah Voisin, Adam J. Herbert, Fleur Garton, Peter J. Houweling, Pawel Cieszczyk, Agnieszka Maciejewska-Skrendo, Marek Sawczuk, Myosotis Massidda, Carla Maria Calò, Irina V. Astratenkova, Anastasia Kouvatsi, Anastasiya M. Druzhevskaya, Macsue Jacques, Ildus I. Ahmetov, Georgina K. Stebbings, Shane Heffernan, Stephen H. Day, Robert Erskine, Charles Pedlar, Courtney Kipps, Kathryn N. North, Alun G. Williams, Nir Eynon |
Abstract |
Studies investigating associations between ACTN3 R577X and ACE I/D genotypes and endurance athletic status have been limited by small sample sizes from mixed sport disciplines and lack quantitative measures of performance. To examine the association between ACTN3 R577X and ACE I/D genotypes and best personal running times in a large homogeneous cohort of endurance runners. We collected a total of 1064 personal best 1500, 3000, 5000 m and marathon running times of 698 male and female Caucasian endurance athletes from six countries (Australia, Greece, Italy, Poland, Russia and UK). Athletes were genotyped for ACTN3 R577X and ACE ID variants. There was no association between ACTN3 R577X or ACE I/D genotype and running performance at any distance in men or women. Mean (SD) marathon times (in s) were for men: ACTN3 RR 9149 (593), RX 9221 (582), XX 9129 (582) p = 0.94; ACE DD 9182 (665), ID 9214 (549), II 9155 (492) p = 0.85; for women: ACTN3 RR 10796 (818), RX 10667 (695), XX 10675 (553) p = 0.36; ACE DD 10604 (561), ID 10766 (740), II 10771 (708) p = 0.21. Furthermore, there were no associations between these variants and running time for any distance in a sub-analysis of athletes with personal records within 20% of world records. Thus, consistent with most case-control studies, this multi-cohort quantitative analysis demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. For ACE II genotype, some prior studies show an association but others do not. Our data indicate it is also unlikely that ACE II genotype provides an advantage in endurance running. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 14 | 47% |
United States | 2 | 7% |
Chile | 1 | 3% |
Australia | 1 | 3% |
Canada | 1 | 3% |
Japan | 1 | 3% |
France | 1 | 3% |
Unknown | 9 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 57% |
Scientists | 13 | 43% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 124 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 15% |
Student > Bachelor | 11 | 9% |
Student > Doctoral Student | 10 | 8% |
Researcher | 7 | 6% |
Lecturer | 6 | 5% |
Other | 32 | 26% |
Unknown | 39 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 33 | 27% |
Medicine and Dentistry | 17 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 7% |
Agricultural and Biological Sciences | 8 | 6% |
Nursing and Health Professions | 3 | 2% |
Other | 16 | 13% |
Unknown | 38 | 31% |