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Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report

Overview of attention for article published in Journal of Medical Case Reports, November 2017
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Title
Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report
Published in
Journal of Medical Case Reports, November 2017
DOI 10.1186/s13256-017-1462-5
Pubmed ID
Authors

Aviva Cohn, Anupam Ohri

Abstract

Glycogen storage disease type Ia is a genetic disorder that is associated with persistent fasting hypoglycemia and the inability to produce endogenous glucose. The development of diabetes with glycogen storage disease is exceedingly rare. The underlying pathogenesis for developing diabetes in these patients is unclear, and there are no guidelines for treatment. We describe a case of a 34-year-old woman of South Asian descent with glycogen storage disease type Ia, who developed uncontrolled diabetes mellitus as a young adult. Hyperglycemia was noted after childbirth, and worsened years later. Treatment for diabetes was difficult due to risks of hypoglycemia from her underlying glycogen storage disease. With minimal hypoglycemic events, the patient's blood glucose improved with exercise in combination with a sodium-glucose co-transporter 2 inhibitor and an alpha glucosidase inhibitor. We report a rare case of diabetes in the setting of glycogen storage disease-Ia. Based on the literature, there appears to be a relationship between glycogen storage disease and metabolic syndrome, which likely plays a role in the pathogenesis. The management of glycemic control remains a clinical challenge, requiring management of both fasting hypoglycemia from glycogen storage disease, as well as post-prandial hyperglycemia from diabetes mellitus.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 14%
Student > Bachelor 12 14%
Student > Ph. D. Student 9 10%
Student > Postgraduate 6 7%
Student > Doctoral Student 5 6%
Other 13 15%
Unknown 31 35%
Readers by discipline Count As %
Medicine and Dentistry 24 27%
Nursing and Health Professions 8 9%
Biochemistry, Genetics and Molecular Biology 3 3%
Social Sciences 3 3%
Chemistry 3 3%
Other 11 13%
Unknown 36 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#20,458,307
of 23,015,156 outputs
Outputs from Journal of Medical Case Reports
#3,511
of 3,946 outputs
Outputs of similar age
#283,985
of 325,838 outputs
Outputs of similar age from Journal of Medical Case Reports
#71
of 73 outputs
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