Title |
Gametocytogenesis : the puberty of Plasmodium falciparum
|
---|---|
Published in |
Malaria Journal, July 2004
|
DOI | 10.1186/1475-2875-3-24 |
Pubmed ID | |
Authors |
Arthur M Talman, Olivier Domarle, F Ellis McKenzie, Frédéric Ariey, Vincent Robert |
Abstract |
The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable biology and adaptive phenotypes to insure its transmission despite the dangers of sex. This review mainly focuses on the current knowledge on commitment to sexual development, gametocytogenesis and the evolutionary significance of various aspects of gametocyte biology. It goes further than pure biology to look at the strategies used to improve successful transmission. Although gametocytes are inevitable stages for transmission and provide a potential target to fight malaria, they have received less attention than the pathogenic asexual stages. There is a need for research on gametocytes, which are a fascinating stage, responsible to a large extent for the success of P. falciparum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 1% |
United Kingdom | 5 | 1% |
Brazil | 2 | <1% |
Kenya | 2 | <1% |
Netherlands | 2 | <1% |
Madagascar | 2 | <1% |
Belgium | 2 | <1% |
India | 2 | <1% |
Germany | 1 | <1% |
Other | 6 | 1% |
Unknown | 450 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 112 | 23% |
Student > Master | 82 | 17% |
Researcher | 77 | 16% |
Student > Bachelor | 53 | 11% |
Student > Postgraduate | 27 | 6% |
Other | 66 | 14% |
Unknown | 62 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 183 | 38% |
Biochemistry, Genetics and Molecular Biology | 94 | 20% |
Medicine and Dentistry | 32 | 7% |
Immunology and Microbiology | 31 | 6% |
Chemistry | 10 | 2% |
Other | 54 | 11% |
Unknown | 75 | 16% |