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Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome

Overview of attention for article published in Particle and Fibre Toxicology, January 2018
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Title
Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome
Published in
Particle and Fibre Toxicology, January 2018
DOI 10.1186/s12989-017-0239-8
Pubmed ID
Authors

P. A. Stapleton, Q. A. Hathaway, C. E. Nichols, A. B. Abukabda, M. V. Pinti, D. L. Shepherd, C. R. McBride, J. Yi, V. C. Castranova, J. M. Hollander, T. R. Nurkiewicz

Abstract

The integration of engineered nanomaterials (ENM) is well-established and widespread in clinical, commercial, and domestic applications. Cardiovascular dysfunctions have been reported in adult populations after exposure to a variety of ENM. As the diversity of these exposures continues to increase, the fetal ramifications of maternal exposures have yet to be determined. We, and others, have explored the consequences of ENM inhalation during gestation and identified many cardiovascular and metabolic outcomes in the F1 generation. The purpose of these studies was to identify genetic alterations in the F1 generation of Sprague-Dawley rats that result from maternal ENM inhalation during gestation. Pregnant dams were exposed to nano-titanium dioxide (nano-TiO2) aerosols (10 ± 0.5 mg/m3) for 7-8 days (calculated, cumulative lung deposition = 217 ± 1 μg) and on GD (gestational day) 20 fetal hearts were isolated. DNA was extracted and immunoprecipitated with modified chromatin marks histone 3 lysine 4 tri-methylation (H3K4me3) and histone 3 lysine 27 tri-methylation (H3K27me3). Following chromatin immunoprecipitation (ChIP), DNA fragments were sequenced. RNA from fetal hearts was purified and prepared for RNA sequencing and transcriptomic analysis. Ingenuity Pathway Analysis (IPA) was then used to identify pathways most modified by gestational ENM exposure. The results of the sequencing experiments provide initial evidence that significant epigenetic and transcriptomic changes occur in the cardiac tissue of maternal nano-TiO2 exposed progeny. The most notable alterations in major biologic systems included immune adaptation and organismal growth. Changes in normal physiology were linked with other tissues, including liver and kidneys. These results are the first evidence that maternal ENM inhalation impacts the fetal epigenome.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 13%
Researcher 4 11%
Student > Master 4 11%
Student > Bachelor 3 8%
Student > Doctoral Student 2 5%
Other 5 13%
Unknown 15 39%
Readers by discipline Count As %
Medicine and Dentistry 6 16%
Biochemistry, Genetics and Molecular Biology 3 8%
Psychology 3 8%
Neuroscience 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 11%
Unknown 18 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#14,992,114
of 25,492,047 outputs
Outputs from Particle and Fibre Toxicology
#356
of 617 outputs
Outputs of similar age
#231,095
of 451,809 outputs
Outputs of similar age from Particle and Fibre Toxicology
#13
of 19 outputs
Altmetric has tracked 25,492,047 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,809 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.