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Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

Overview of attention for article published in BMC Clinical Pathology, December 2017
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Title
Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
Published in
BMC Clinical Pathology, December 2017
DOI 10.1186/s12907-017-0067-7
Pubmed ID
Authors

Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford, Emma J. Crosbie

Abstract

Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered energy metabolism is a hallmark of malignancy. Cancer cells drive tumour growth through aerobic glycolysis and must export lactate to maintain intracellular pH. The aim of this study was to evaluate the expression of the lactate/proton monocarboxylate transporters MCT1 and MCT4 and their chaperone CD147 in EC, with the ultimate aim of directing future drug development. MCT1, MCT4 and CD147 expression was examined using immunohistochemical analysis in 90 endometrial tumours and correlated with clinico-pathological characteristics and survival outcomes. MCT1 and MCT4 expression was observed in the cytoplasm, the plasma membrane or both locations. CD147 was detected in the plasma membrane and associated with MCT1 (p = 0.003) but not with MCT4 (p = 0.207) expression. High MCT1 expression was associated with reduced overall survival (p = 0.029) and remained statistically significant after adjustment for survival covariates (p = 0.017). Our data suggest that MCT1 expression is an important marker of poor prognosis in EC. MCT1 inhibition may have potential as a treatment for advanced or recurrent EC.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 29%
Student > Master 4 17%
Researcher 4 17%
Student > Bachelor 1 4%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 3 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 5 21%
Biochemistry, Genetics and Molecular Biology 5 21%
Medicine and Dentistry 4 17%
Chemistry 3 13%
Immunology and Microbiology 2 8%
Other 3 13%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2018.
All research outputs
#9,891,513
of 12,352,780 outputs
Outputs from BMC Clinical Pathology
#67
of 111 outputs
Outputs of similar age
#255,510
of 354,944 outputs
Outputs of similar age from BMC Clinical Pathology
#2
of 2 outputs
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