↓ Skip to main content

Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes

Overview of attention for article published in Retrovirology, March 2005
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

patent
3 patents
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
96 Dimensions

Readers on

mendeley
66 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes
Published in
Retrovirology, March 2005
DOI 10.1186/1742-4690-2-19
Pubmed ID
Authors

Sandra Blaise, Nathalie de Parseval, Thierry Heidmann

Abstract

A recent in silico search for coding sequences of retroviral origin present in the human genome has unraveled two new envelope genes that add to the 16 genes previously identified. A systematic search among the latter for a fusogenic activity had led to the identification of two bona fide genes, named syncytin-1 and syncytin-2, most probably co-opted by primate genomes for a placental function related to the formation of the syncytiotrophoblast by cell-cell fusion. Here, we show that one of the newly identified envelope gene, named envP(b), is fusogenic in an ex vivo assay, but that its expression - as quantified by real-time RT-PCR on a large panel of human tissues - is ubiquitous, albeit with a rather low value in most tissues. Conversely, the second envelope gene, named envV, discloses a placenta-specific expression, but is not fusogenic in any of the cells tested. Altogether, these results suggest that at least one of these env genes may play a role in placentation, but most probably through a process different from that of the two previously identified syncytins.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Japan 1 2%
France 1 2%
Brazil 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 24%
Student > Bachelor 13 20%
Student > Ph. D. Student 9 14%
Student > Master 7 11%
Student > Doctoral Student 3 5%
Other 9 14%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 36%
Biochemistry, Genetics and Molecular Biology 18 27%
Medicine and Dentistry 5 8%
Immunology and Microbiology 5 8%
Veterinary Science and Veterinary Medicine 1 2%
Other 1 2%
Unknown 12 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2017.
All research outputs
#3,271,154
of 22,780,967 outputs
Outputs from Retrovirology
#156
of 1,106 outputs
Outputs of similar age
#6,089
of 59,400 outputs
Outputs of similar age from Retrovirology
#2
of 7 outputs
Altmetric has tracked 22,780,967 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.