Title |
High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction
|
---|---|
Published in |
BioMedical Engineering OnLine, November 2011
|
DOI | 10.1186/1475-925x-10-102 |
Pubmed ID | |
Authors |
Christopher B Arena, Michael B Sano, John H Rossmeisl, John L Caldwell, Paulo A Garcia, Marissa Nichole Rylander, Rafael V Davalos |
Abstract |
Therapeutic irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors. The technique involves delivering a series of unipolar electric pulses to permanently destabilize the plasma membrane of cancer cells through an increase in transmembrane potential, which leads to the development of a tissue lesion. Clinically, IRE requires the administration of paralytic agents to prevent muscle contractions during treatment that are associated with the delivery of electric pulses. This study shows that by applying high-frequency, bipolar bursts, muscle contractions can be eliminated during IRE without compromising the non-thermal mechanism of cell death. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 212 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
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Researcher | 36 | 17% |
Student > Bachelor | 19 | 9% |
Student > Master | 17 | 8% |
Student > Doctoral Student | 13 | 6% |
Other | 31 | 14% |
Unknown | 53 | 25% |
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Physics and Astronomy | 4 | 2% |
Other | 18 | 8% |
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