Title |
NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b
|
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Published in |
Virology Journal, June 2011
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DOI | 10.1186/1743-422x-8-317 |
Pubmed ID | |
Authors |
Muhammad T Sarwar, Humera Kausar, Bushra Ijaz, Waqar Ahmad, Muhammad Ansar, Aleena Sumrin, Usman A Ashfaq, Sultan Asad, Sana Gull, Imran Shahid, Sajida Hassan |
Abstract |
The 9.6 kb long RNA genome of Hepatitis C virus (HCV) is under the control of RNA dependent RNA polymerase, an error-prone enzyme, for its transcription and replication. A high rate of mutation has been found to be associated with RNA viruses like HCV. Based on genetic variability, HCV has been classified into 6 different major genotypes and 11 different subtypes. However this classification system does not provide significant information about the origin of the virus, primarily due to high mutation rate at nucleotide level. HCV genome codes for a single polyprotein of about 3011 amino acids which is processed into structural and non-structural proteins inside host cell by viral and cellular proteases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 30% |
Student > Master | 5 | 17% |
Student > Bachelor | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Researcher | 2 | 7% |
Other | 4 | 13% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 27% |
Medicine and Dentistry | 6 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Immunology and Microbiology | 3 | 10% |
Computer Science | 2 | 7% |
Other | 0 | 0% |
Unknown | 7 | 23% |