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PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

Overview of attention for article published in BMC Biology, January 2018
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Title
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
Published in
BMC Biology, January 2018
DOI 10.1186/s12915-017-0470-7
Pubmed ID
Authors

Shiori Sekine, Richard J. Youle

Abstract

Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy mitochondrial network, is initiated by activation of the PINK1 kinase specifically on damaged mitochondria. Recent investigation of this process reveals that import of PINK1 into mitochondria is regulated and yields a stress-sensing mechanism. In this review, we focus on the mechanisms of mitochondrial stress-dependent PINK1 activation that is exerted by regulated import of PINK1 into different mitochondrial compartments and how this offers strategies to pharmacologically activate the PINK1/Parkin pathway.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 236 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 19%
Student > Bachelor 36 15%
Student > Master 30 13%
Researcher 29 12%
Student > Doctoral Student 8 3%
Other 21 9%
Unknown 66 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 81 34%
Agricultural and Biological Sciences 33 14%
Neuroscience 22 9%
Medicine and Dentistry 12 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 10 4%
Unknown 71 30%