Title |
A case of molecularly profiled extraneural medulloblastoma metastases in a child
|
---|---|
Published in |
BMC Medical Genetics, January 2018
|
DOI | 10.1186/s12881-018-0526-8 |
Pubmed ID | |
Authors |
Nahla Ali Mobark, Musa Al-Harbi, Othman Mosleh, Sandro Santagata, Matija Snuderl, Malak Abedalthagafi |
Abstract |
Extraneural metastases are relatively rare manifestations of medulloblastoma. We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child. |
Twitter Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Saudi Arabia | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 10% |
Researcher | 2 | 10% |
Student > Bachelor | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Lecturer | 1 | 5% |
Other | 5 | 24% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 43% |
Chemical Engineering | 1 | 5% |
Physics and Astronomy | 1 | 5% |
Unspecified | 1 | 5% |
Unknown | 9 | 43% |