Title |
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) Study
|
---|---|
Published in |
Nutrition Journal, February 2009
|
DOI | 10.1186/1475-2891-8-14 |
Pubmed ID | |
Authors |
Aurelian Bidulescu, Lloyd E Chambless, Anna Maria Siega-Riz, Steven H Zeisel, Gerardo Heiss |
Abstract |
The repeatability of a risk factor measurement affects the ability to accurately ascertain its association with a specific outcome. Choline is involved in methylation of homocysteine, a putative risk factor for cardiovascular disease, to methionine through a betaine-dependent pathway (one-carbon metabolism). It is unknown whether dietary intake of choline meets the recommended Adequate Intake (AI) proposed for choline (550 mg/day for men and 425 mg/day for women). The Estimated Average Requirement (EAR) remains to be established in population settings. Our objectives were to ascertain the reliability of choline and related nutrients (folate and methionine) intakes assessed with a brief food frequency questionnaire (FFQ) and to estimate dietary intake of choline and betaine in a bi-ethnic population. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 47 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 24% |
Student > Ph. D. Student | 9 | 18% |
Student > Bachelor | 7 | 14% |
Professor > Associate Professor | 5 | 10% |
Student > Master | 4 | 8% |
Other | 7 | 14% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 36% |
Agricultural and Biological Sciences | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Neuroscience | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Other | 4 | 8% |
Unknown | 8 | 16% |