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The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder

Overview of attention for article published in BMC Psychiatry, January 2018
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Title
The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder
Published in
BMC Psychiatry, January 2018
DOI 10.1186/s12888-018-1604-3
Pubmed ID
Authors

Martin Fungisai Gerchen, Martina Kirsch, Nathalie Bahs, Patrick Halli, Sarah Gerhardt, Axel Schäfer, Wolfgang H. Sommer, Falk Kiefer, Peter Kirsch

Abstract

Alcohol Use Disorder is a highly prevalent mental disorder which puts a severe burden on individuals, families, and society. The treatment of Alcohol Use Disorder is challenging and novel and innovative treatment approaches are needed to expand treatment options. A promising neuroscience-based intervention method that allows targeting cortical as well as subcortical brain processes is real-time functional magnetic resonance imaging neurofeedback. However, the efficacy of this technique as an add-on treatment of Alcohol Use Disorder in a clinical setting is hitherto unclear and will be assessed in the Systems Biology of Alcohol Addiction (SyBil-AA) neurofeedback study. N = 100 patients with Alcohol Use Disorder will be randomized to 5 parallel groups in a single-blind fashion and receive real-time functional magnetic resonance imaging neurofeedback while they are presented pictures of alcoholic beverages. The groups will either downregulate the ventral striatum, upregulate the right inferior frontal gyrus, negatively modulate the connectivity between these regions, upregulate, or downregulate the auditory cortex as a control region. After receiving 3 sessions of neurofeedback training within a maximum of 2 weeks, participants will be followed up monthly for a period of 3 months and relapse rates will be assessed as the primary outcome measure. The results of this study will provide insights into the efficacy of real-time functional magnetic resonance imaging neurofeedback training in the treatment of Alcohol Use Disorder as well as in the involved brain systems. This might help to identify predictors of successful neurofeedback treatment which could potentially be useful in developing personalized treatment approaches. The study was retrospectively registered in the German Clinical Trials Register (trial identifier: DRKS00010253 ; WHO Universal Trial Number (UTN): U1111-1181-4218) on May 10th, 2016.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 125 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 13%
Student > Master 13 10%
Researcher 12 10%
Student > Ph. D. Student 11 9%
Student > Doctoral Student 10 8%
Other 28 22%
Unknown 35 28%
Readers by discipline Count As %
Psychology 29 23%
Medicine and Dentistry 16 13%
Nursing and Health Professions 10 8%
Neuroscience 9 7%
Social Sciences 5 4%
Other 11 9%
Unknown 45 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2018.
All research outputs
#19,013,042
of 24,226,848 outputs
Outputs from BMC Psychiatry
#4,012
of 5,080 outputs
Outputs of similar age
#320,486
of 450,103 outputs
Outputs of similar age from BMC Psychiatry
#73
of 88 outputs
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