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Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis

Overview of attention for article published in BMC Cancer, December 2017
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Title
Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis
Published in
BMC Cancer, December 2017
DOI 10.1186/s12885-017-3839-7
Pubmed ID
Authors

Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui, Yi Jin

Abstract

Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. In the present study, the expression of Cullin7 in hepatocellular carcinoma cell lines and five surgical hepatocellular carcinoma specimens was detected with quantitative reverse transcription PCR and western blotting. In addition, the protein expression of Cullin7 was examined in 162 cases of archived hepatocellular carcinoma using immunohistochemistry. We found elevated expression of both mRNA and protein levels of Cullin7 in hepatocellular carcinoma cell lines, and Cullin7 protein was significantly upregulated in hepatocellular carcinoma compared with paired normal hepatic tissues. The immunohistochemistry analysis revealed that overexpression of Cullin7 occurred in 69.1% of hepatocellular carcinoma samples, which was a significantly higher rate than that in adjacent normal hepatic tissue (P < 0.01). Statistical analysis found that overexpression of Cullin7 was significantly associated with lymph node metastasis, tumor thrombus of the portal vein and advanced clinical stage (P < 0.05). Furthermore, by overexpressing Cullin7 in hepatocellular carcinoma HepG2 cells, we revealed that Cullin7 could significantly enhance cell proliferation, growth, migration and invasion. Conversely, knocking down Cullin7 expression with short hairpin RNAi in hepatocellular carcinoma HepG2 cells inhibited cell proliferation, growth, migration and invasion. Our studies provide evidence that overexpression of Cullin7 plays an important role in the pathogenesis and progression of hepatocellular carcinoma and may be a valuable marker for hepatocellular carcinoma management.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 18%
Librarian 1 9%
Other 1 9%
Student > Bachelor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Unknown 3 27%
Readers by discipline Count As %
Medicine and Dentistry 5 45%
Biochemistry, Genetics and Molecular Biology 1 9%
Social Sciences 1 9%
Nursing and Health Professions 1 9%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2018.
All research outputs
#12,218,997
of 13,801,769 outputs
Outputs from BMC Cancer
#4,208
of 5,209 outputs
Outputs of similar age
#299,632
of 355,093 outputs
Outputs of similar age from BMC Cancer
#4
of 4 outputs
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