Title |
Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model
|
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Published in |
Immunity & Ageing, April 2009
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DOI | 10.1186/1742-4933-6-4 |
Pubmed ID | |
Authors |
Henrique Douglas M Coutinho, Vivyanne S Falcão-Silva, Gregório Fernandes Gonçalves, Raphael Batista da Nóbrega |
Abstract |
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24, have been found in patients with HGPS. The p.G608G LMNA mutation is the most commonly reported mutation. The aim of this work was to compile a comprehensive literature review of the clinical features and genetic mutations and mechanisms of this syndrome as a contribution to health care workers. This review shows the necessity of a more detailed clinical identification of Hutchinson-Gilford progeria syndrome and the need for more studies on the pharmacologic and pharmacogenomic approach to this syndrome. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
France | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 161 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 45 | 27% |
Student > Ph. D. Student | 30 | 18% |
Student > Master | 23 | 14% |
Researcher | 14 | 8% |
Student > Postgraduate | 8 | 5% |
Other | 21 | 12% |
Unknown | 28 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 55 | 33% |
Agricultural and Biological Sciences | 51 | 30% |
Medicine and Dentistry | 9 | 5% |
Engineering | 4 | 2% |
Chemistry | 4 | 2% |
Other | 11 | 7% |
Unknown | 35 | 21% |