Title |
Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing
|
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Published in |
BMC Ecology and Evolution, October 2007
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DOI | 10.1186/1471-2148-7-188 |
Pubmed ID | |
Authors |
Manuel Irimia, Jakob Lewin Rukov, David Penny, Scott William Roy |
Abstract |
Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic groups or was inherited from their last common ancestor, and may therefore predate multicellularity, is still unknown. To better understand the origin and evolution of alternative splicing and its usage in diverse organisms, we studied alternative splicing in 12 eukaryotic species, comparing rates of alternative splicing across genes of different functional classes, cellular locations, intron/exon structures and evolutionary origins. |
Mendeley readers
Geographical breakdown
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United States | 3 | 3% |
Brazil | 2 | 2% |
Spain | 2 | 2% |
Switzerland | 1 | 1% |
New Zealand | 1 | 1% |
Australia | 1 | 1% |
Germany | 1 | 1% |
Luxembourg | 1 | 1% |
Unknown | 81 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 25% |
Researcher | 20 | 22% |
Student > Master | 12 | 13% |
Student > Bachelor | 8 | 9% |
Professor > Associate Professor | 6 | 6% |
Other | 12 | 13% |
Unknown | 12 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 14% |
Computer Science | 3 | 3% |
Environmental Science | 2 | 2% |
Medicine and Dentistry | 2 | 2% |
Other | 5 | 5% |
Unknown | 17 | 18% |