Title |
Cancer dormancy and criticality from a game theory perspective
|
---|---|
Published in |
Cancer Convergence, January 2018
|
DOI | 10.1186/s41236-018-0008-0 |
Pubmed ID | |
Authors |
Amy Wu, David Liao, Vlamimir Kirilin, Ke-Chih Lin, Gonzalo Torga, Junle Qu, Liyu Liu, James C. Sturm, Kenneth Pienta, Robert Austin |
Abstract |
The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy. We explore here the dynamics of host-cancer cell populations in the presence of (1) payoffs gradients and (2) perturbations due to cell migration. We determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 63% |
Taiwan | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 50% |
Scientists | 4 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 11% |
Student > Bachelor | 2 | 11% |
Researcher | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 1 | 5% |
Other | 4 | 21% |
Unknown | 6 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Physics and Astronomy | 4 | 21% |
Agricultural and Biological Sciences | 1 | 5% |
Computer Science | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Other | 2 | 11% |
Unknown | 6 | 32% |