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Two-step interphase microtubule disassembly aids spindle morphogenesis

Overview of attention for article published in BMC Biology, January 2018
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  • Good Attention Score compared to outputs of the same age (68th percentile)

Mentioned by

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10 tweeters

Citations

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19 Dimensions

Readers on

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38 Mendeley
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Title
Two-step interphase microtubule disassembly aids spindle morphogenesis
Published in
BMC Biology, January 2018
DOI 10.1186/s12915-017-0478-z
Pubmed ID
Authors

Nunu Mchedlishvili, Helen K. Matthews, Adam Corrigan, Buzz Baum

Abstract

Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase microtubule disassembly. First, a microtubule-stabilising protein, Ensconsin/MAP7, is inactivated in prophase as a consequence of its phosphorylation downstream of Cdk1/cyclin B. This leads to a reduction in interphase microtubule stability that may help to fuel the growth of centrosomally nucleated microtubules. The peripheral interphase microtubules that remain are then rapidly lost as the concentration of tubulin heterodimers falls following dissolution of the nuclear compartment boundary. Finally, we show that a failure to destabilise microtubules in prophase leads to the formation of microtubule clumps, which interfere with spindle assembly. This analysis highlights the importance of the step-wise remodelling of the microtubule cytoskeleton and the significance of permeabilisation of the nuclear envelope in coordinating the changes in cellular organisation and biochemistry that accompany mitotic entry.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 34%
Researcher 9 24%
Student > Master 4 11%
Student > Doctoral Student 3 8%
Professor 3 8%
Other 2 5%
Unknown 4 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 66%
Agricultural and Biological Sciences 6 16%
Engineering 1 3%
Unknown 6 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2019.
All research outputs
#4,528,271
of 16,341,511 outputs
Outputs from BMC Biology
#910
of 1,422 outputs
Outputs of similar age
#115,531
of 370,303 outputs
Outputs of similar age from BMC Biology
#1
of 2 outputs
Altmetric has tracked 16,341,511 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,422 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,303 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them