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Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine

Overview of attention for article published in BMC Genomics, January 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

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Title
Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine
Published in
BMC Genomics, January 2018
DOI 10.1186/s12864-018-4450-2
Pubmed ID
Authors

Zachary F. Gerring, Allan F. McRae, Grant W. Montgomery, Dale R. Nyholt

Abstract

Migraine is a common heritable neurovascular disorder typically characterised by episodic attacks of severe pulsating headache and nausea, often accompanied by visual, auditory or other sensory symptoms. Although genome-wide association studies have identified over 40 single nucleotide polymorphisms associated with migraine, there remains uncertainty about the casual genes involved in disease pathogenesis and how their function is regulated. We performed an epigenome-wide association study, quantifying genome-wide patterns of DNA methylation in 67 migraine cases and 67 controls with a matching age and sex distribution. Association analyses between migraine and methylation probe expression, after adjustment for cell type proportions, indicated an excess of small P values, but there was no significant single-probe association after correction for multiple testing (P < 1.09 × 10- 7). However, utilising a 1 kb sliding window approach to combine adjacent migraine-methylation association P values, we identified 62 independent differentially methylated regions (DMRs) underlying migraine (false discovery rate < 0.05). Migraine association signals were subtle but consistent in effect direction across the length of each DMR. Subsequent analyses showed that the migraine-associated DMRs were enriched in regulatory elements of the genome and were in close proximity to genes involved in solute transportation and haemostasis. This study represents the first genome-wide analysis of DNA methylation in migraine. We have identified DNA methylation in the whole blood of subjects associated with migraine, highlighting novel loci that provide insight into the biological pathways and mechanisms underlying migraine pathogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 22%
Student > Ph. D. Student 13 17%
Student > Master 8 11%
Student > Postgraduate 7 9%
Other 6 8%
Other 13 17%
Unknown 12 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 17%
Neuroscience 12 16%
Medicine and Dentistry 8 11%
Psychology 4 5%
Agricultural and Biological Sciences 4 5%
Other 14 18%
Unknown 21 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#2,818,114
of 23,767,404 outputs
Outputs from BMC Genomics
#942
of 10,807 outputs
Outputs of similar age
#65,407
of 444,637 outputs
Outputs of similar age from BMC Genomics
#23
of 202 outputs
Altmetric has tracked 23,767,404 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,807 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 444,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 202 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.