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Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine

Overview of attention for article published in BMC Genomics, January 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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13 tweeters
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2 Facebook pages
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1 Google+ user

Citations

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17 Dimensions

Readers on

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52 Mendeley
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Title
Genome-wide DNA methylation profiling in whole blood reveals epigenetic signatures associated with migraine
Published in
BMC Genomics, January 2018
DOI 10.1186/s12864-018-4450-2
Pubmed ID
Authors

Zachary F. Gerring, Allan F. McRae, Grant W. Montgomery, Dale R. Nyholt

Abstract

Migraine is a common heritable neurovascular disorder typically characterised by episodic attacks of severe pulsating headache and nausea, often accompanied by visual, auditory or other sensory symptoms. Although genome-wide association studies have identified over 40 single nucleotide polymorphisms associated with migraine, there remains uncertainty about the casual genes involved in disease pathogenesis and how their function is regulated. We performed an epigenome-wide association study, quantifying genome-wide patterns of DNA methylation in 67 migraine cases and 67 controls with a matching age and sex distribution. Association analyses between migraine and methylation probe expression, after adjustment for cell type proportions, indicated an excess of small P values, but there was no significant single-probe association after correction for multiple testing (P < 1.09 × 10- 7). However, utilising a 1 kb sliding window approach to combine adjacent migraine-methylation association P values, we identified 62 independent differentially methylated regions (DMRs) underlying migraine (false discovery rate < 0.05). Migraine association signals were subtle but consistent in effect direction across the length of each DMR. Subsequent analyses showed that the migraine-associated DMRs were enriched in regulatory elements of the genome and were in close proximity to genes involved in solute transportation and haemostasis. This study represents the first genome-wide analysis of DNA methylation in migraine. We have identified DNA methylation in the whole blood of subjects associated with migraine, highlighting novel loci that provide insight into the biological pathways and mechanisms underlying migraine pathogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 21%
Student > Ph. D. Student 10 19%
Student > Postgraduate 7 13%
Student > Master 6 12%
Other 4 8%
Other 11 21%
Unknown 3 6%
Readers by discipline Count As %
Neuroscience 8 15%
Medicine and Dentistry 7 13%
Biochemistry, Genetics and Molecular Biology 7 13%
Psychology 4 8%
Agricultural and Biological Sciences 4 8%
Other 12 23%
Unknown 10 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2018.
All research outputs
#2,012,161
of 15,922,193 outputs
Outputs from BMC Genomics
#895
of 8,861 outputs
Outputs of similar age
#63,019
of 368,000 outputs
Outputs of similar age from BMC Genomics
#2
of 25 outputs
Altmetric has tracked 15,922,193 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,861 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,000 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.