Title |
CILIA: before and after
|
---|---|
Published in |
Cilia, March 2017
|
DOI | 10.1186/s13630-017-0046-8 |
Pubmed ID | |
Authors |
Peter Satir |
Abstract |
This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Unknown | 170 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 21% |
Student > Master | 29 | 17% |
Researcher | 27 | 16% |
Student > Bachelor | 19 | 11% |
Professor > Associate Professor | 9 | 5% |
Other | 24 | 14% |
Unknown | 30 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 57 | 33% |
Agricultural and Biological Sciences | 35 | 20% |
Medicine and Dentistry | 17 | 10% |
Neuroscience | 13 | 7% |
Engineering | 6 | 3% |
Other | 10 | 6% |
Unknown | 36 | 21% |