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Claudin expression during early postnatal development of the murine cochlea

Overview of attention for article published in BMC Physiology, January 2018
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Title
Claudin expression during early postnatal development of the murine cochlea
Published in
BMC Physiology, January 2018
DOI 10.1186/s12899-018-0035-1
Pubmed ID
Authors

Takayuki Kudo, Philine Wangemann, Daniel C. Marcus

Abstract

Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference and the large concentration differences of K+, Na+ and Ca2+ needed for normal cochlear function. Claudins are a family of more than 20 subtypes, but our knowledge about expression and localization of each subtype in the cochlea is limited. We examined by quantitative RT-PCR the expression of the mRNA of 24 claudin isoforms in mouse cochlea during postnatal development and localized the expression in separated fractions of the cochlea. Transcripts of 21 claudin isoforms were detected at all ages, while 3 isoforms (Cldn-16, - 17 and - 18) were not detected. Claudins that increased expression during development include Cldn-9, - 13, - 14, - 15, and -19v2, while Cldn-6 decreased. Those that do not change expression level during postnatal development include Cldn-1, - 2, - 3, - 4, - 5, - 7, - 8, -10v1, -10v2, - 11, - 12, -19v1, - 20, - 22, and - 23. Our investigation revealed unique localization of some claudins. In particular, Cldn-13 expression rapidly increases during early development and is mainly expressed in bone but only minimally in the lateral wall (including stria vascularis) and in the medial region (including the organ of Corti). No statistically significant changes in expression of Cldn-11, - 13, or - 14 were found in the cochlea of Slc26a4 -/- mice compared to Slc26a4 +/- mice. We demonstrated developmental patterns of claudin isoform transcript expression in the murine cochlea. Most of the claudins were associated with stria vascularis and organ of Corti, tissue fractions rich in tight junctions. However, this study suggests a novel function of Cldn-13 in the cochlea, which may be linked to cochlear bone marrow maturation.

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Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 42%
Other 2 17%
Student > Master 2 17%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Other 1 8%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Neuroscience 3 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Agricultural and Biological Sciences 1 8%
Other 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2018.
All research outputs
#15,489,831
of 23,018,998 outputs
Outputs from BMC Physiology
#55
of 87 outputs
Outputs of similar age
#269,977
of 441,125 outputs
Outputs of similar age from BMC Physiology
#1
of 3 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 87 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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