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Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

Overview of attention for article published in Journal of Translational Medicine, February 2015
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Title
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma
Published in
Journal of Translational Medicine, February 2015
DOI 10.1186/s12967-015-0396-1
Pubmed ID
Authors

Jia-hong Wang, Wei Wei, Zhi-xing Guo, Ming Shi, Rong-ping Guo

Abstract

BackgroundDeubiquitinases, such as CYLD, A20 and Cezanne, have emerged as negative regulators that balance the strength and duration of NF-¿B signaling through feedback mechanisms. However, how these serial feedback loops are simultaneously disrupted in cancer remains unclear. The purpose of this study is to investigate the correlation of Cezanne expression with clinicopathological/prognostic value in hepatocellular carcinoma (HCC).MethodsThe expression levels of Cezanne and matrix metallopeptidase 9 (MMP-9) were assessed by immunohistochemistry in 230 HCC specimens. The correlation between expression of Cezanne and MMP-9, clinicopathological/prognostic value in hepatocellular carcinoma was examined.ResultsCezanne reduction in HCC was significantly associated with larger tumor, satellite nodule, vascular invasion, TNM stage, BCLC stage and early recurrence. Kaplan-Meier analysis showed that Cezanne was a great predictive factor for overall survival (OS) and time to recurrence (TTR). The expression of Cezanne was decreased in TNM and BCLC stage-dependent manner. In addition, Cezanne reduction was associated with poor prognosis in patients subgroups stratified by tumor size, tumor differentiation, TNM stage and BCLC stage. Moreover, Cezanne was negatively associated with MMP-9 among 230 HCC samples. Patients who had Cezanne downregulation, in which cancer cells showed high invasiveness, had shorter TTR and poor OS. Furthermore, the coindex of Cezanne and preoperative serum AFP levels was significantly correlated with OS and TTR.ConclusionCezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in HCC patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Student > Ph. D. Student 4 22%
Researcher 2 11%
Professor 1 6%
Librarian 1 6%
Other 2 11%
Unknown 4 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 17%
Medicine and Dentistry 3 17%
Agricultural and Biological Sciences 2 11%
Immunology and Microbiology 2 11%
Nursing and Health Professions 1 6%
Other 2 11%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2015.
All research outputs
#14,797,632
of 22,783,848 outputs
Outputs from Journal of Translational Medicine
#1,973
of 3,987 outputs
Outputs of similar age
#198,837
of 352,508 outputs
Outputs of similar age from Journal of Translational Medicine
#58
of 112 outputs
Altmetric has tracked 22,783,848 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,987 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.