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Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator

Overview of attention for article published in BMC Physiology, January 2018
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Title
Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator
Published in
BMC Physiology, January 2018
DOI 10.1186/s12899-018-0036-0
Pubmed ID
Authors

Jessica A. Krizo, Linley E. Moreland, Ashutosh Rastogi, Xiang Mou, Rebecca A. Prosser, Eric M. Mintz

Abstract

Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is synchronized to environmental day/night cycles by photic input, which is dependent on the presence of mature brain-derived neurotrophic factor (BDNF) in the SCN. Mature BDNF is produced by the enzyme plasmin, which is converted from plasminogen by the enzyme tissue-type plasminogen activator (tPA). In this study, we evaluate circadian function in mice lacking functional tPA. tPA-/- mice have normal circadian periods, but show decreased nocturnal wheel-running activity. This difference is eliminated or reversed on the second day of a 48-h fast. Similarly, when placed on daily cycles of restricted food availability the genotypic difference in total wheel-running activity disappears, and tPA-/- mice show equivalent amounts of food anticipatory activity to wild type mice. These data suggest that tPA regulates nocturnal wheel-running activity, and that tPA differentially affects SCN-driven nocturnal activity rhythms and activity driven by fasting or temporal food restriction.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 21%
Student > Ph. D. Student 3 16%
Student > Bachelor 3 16%
Researcher 2 11%
Professor 2 11%
Other 4 21%
Unknown 1 5%
Readers by discipline Count As %
Neuroscience 6 32%
Biochemistry, Genetics and Molecular Biology 4 21%
Medicine and Dentistry 2 11%
Agricultural and Biological Sciences 1 5%
Social Sciences 1 5%
Other 0 0%
Unknown 5 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2018.
All research outputs
#9,944,759
of 12,422,276 outputs
Outputs from BMC Physiology
#55
of 77 outputs
Outputs of similar age
#246,485
of 340,058 outputs
Outputs of similar age from BMC Physiology
#1
of 1 outputs
Altmetric has tracked 12,422,276 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 77 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them