Title |
Proliferation dynamics of germinative zone cells in the intact and excitotoxically lesioned postnatal rat brain
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Published in |
BMC Neuroscience, April 2005
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DOI | 10.1186/1471-2202-6-26 |
Pubmed ID | |
Authors |
Maryam Faiz, Laia Acarin, Bernardo Castellano, Berta Gonzalez |
Abstract |
The forebrain subventricular zone (SVZ)-olfactory bulb pathway and hippocampal subgranular zone (SGZ) generate neurons into adulthood in the mammalian brain. Neurogenesis increases after injury to the adult brain, but few studies examine the effect of injury on neural and glial precursors in the postnatal brain. To characterize the spatio-temporal dynamics of cell proliferation in the germinative zones, this study utilized a model of postnatal damage induced by NMDA injection in the right sensorimotor cortex at postnatal day 9. Dividing cell populations were labeled with 5-Bromodeoxyuridine (BrdU) in the intact and damaged postnatal brain. Identity of proliferating cells was determined by double immunolabeling with nestin, GFAP, NeuN and tomato lectin (TL). |
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