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Mendeley readers
Attention Score in Context
| Title |
The emerging roles of CDK12 in tumorigenesis
|
|---|---|
| Published in |
Cell Division, October 2017
|
| DOI | 10.1186/s13008-017-0033-x |
| Pubmed ID | |
| Authors |
Hana Paculová, Jiří Kohoutek |
| Abstract |
Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase which participates in various cellular processes, including DNA damage response, development and cellular differentiation, as well as splicing and pre-mRNA processing. CDK12 mutations and amplification have been recently reported in different types of malignancies, including loss-of-function mutations in high-grade serous ovarian carcinomas, and that has led to assumption that CDK12 is a tumor suppressor. On the contrary, CDK12 overexpression in other tumors suggests the possibility that CDK12 has oncogenic properties, similarly to other transcription-associated kinases. In this review, we discuss current knowledge concerning the role of CDK12 in ovarian and breast tumorigenesis and the potential for chemical inhibitors of CDK12 in future cancer treatment. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 19% |
| Student > Ph. D. Student | 15 | 15% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 8 | 8% |
| Other | 11 | 11% |
| Unknown | 23 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 38% |
| Medicine and Dentistry | 14 | 14% |
| Agricultural and Biological Sciences | 10 | 10% |
| Chemistry | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 23 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2018.
All research outputs
#4,223,900
of 23,018,998 outputs
Outputs from Cell Division
#14
of 132 outputs
Outputs of similar age
#77,468
of 328,346 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them