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Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis

Overview of attention for article published in Breast Cancer Research, October 2002
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2 Wikipedia pages

Citations

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199 Dimensions

Readers on

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102 Mendeley
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Title
Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
Published in
Breast Cancer Research, October 2002
DOI 10.1186/bcr452
Pubmed ID
Authors

Elizabeth Anderson

Abstract

A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERalpha) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERalpha expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERalpha and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 2%
Turkey 1 <1%
Chile 1 <1%
Argentina 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
Serbia 1 <1%
Unknown 94 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 18%
Student > Ph. D. Student 16 16%
Student > Master 15 15%
Student > Bachelor 11 11%
Other 7 7%
Other 19 19%
Unknown 16 16%
Readers by discipline Count As %
Medicine and Dentistry 30 29%
Biochemistry, Genetics and Molecular Biology 23 23%
Agricultural and Biological Sciences 18 18%
Neuroscience 3 3%
Nursing and Health Professions 2 2%
Other 8 8%
Unknown 18 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2018.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Breast Cancer Research
#977
of 2,052 outputs
Outputs of similar age
#17,269
of 49,679 outputs
Outputs of similar age from Breast Cancer Research
#3
of 5 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 49,679 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.