Title |
Experimental evaluation of the relationship between lethal or non-lethal virulence and transmission success in malaria parasite infections
|
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Published in |
BMC Ecology and Evolution, September 2004
|
DOI | 10.1186/1471-2148-4-30 |
Pubmed ID | |
Authors |
REL Paul, T Lafond, CDM Müller-Graf, S Nithiuthai, PT Brey, JC Koella |
Abstract |
Evolutionary theory suggests that the selection pressure on parasites to maximize their transmission determines their optimal host exploitation strategies and thus their virulence. Establishing the adaptive basis to parasite life history traits has important consequences for predicting parasite responses to public health interventions. In this study we examine the extent to which malaria parasites conform to the predicted adaptive trade-off between transmission and virulence, as defined by mortality. The majority of natural infections, however, result in sub-lethal virulent effects (e.g. anaemia) and are often composed of many strains. Both sub-lethal effects and pathogen population structure have been theoretically shown to have important consequences for virulence evolution. Thus, we additionally examine the relationship between anaemia and transmission in single and mixed clone infections. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
United Kingdom | 2 | 2% |
Brazil | 1 | 1% |
Portugal | 1 | 1% |
France | 1 | 1% |
Lithuania | 1 | 1% |
Unknown | 83 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 22% |
Student > Ph. D. Student | 17 | 19% |
Student > Master | 14 | 15% |
Student > Bachelor | 11 | 12% |
Professor | 7 | 8% |
Other | 18 | 20% |
Unknown | 4 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 57% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Environmental Science | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Medicine and Dentistry | 3 | 3% |
Other | 13 | 14% |
Unknown | 8 | 9% |