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Synergistic effect of eugenol with Colistin against clinical isolated Colistin-resistant Escherichia coli strains

Overview of attention for article published in Antimicrobial Resistance and Infection Control, January 2018
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Mentioned by

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3 tweeters

Citations

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29 Dimensions

Readers on

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69 Mendeley
Summary Twitter Dimensions citations
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Title
Synergistic effect of eugenol with Colistin against clinical isolated Colistin-resistant Escherichia coli strains
Published in
Antimicrobial Resistance and Infection Control, January 2018
DOI 10.1186/s13756-018-0303-7
Pubmed ID
29423192
Authors

Yi-ming Wang, Ling-cong Kong, Jie Liu, Hong-xia Ma

Abstract

Bacterial infections have become more challenging to treat due to the emergence of multidrug-resistant pathogenic bacteria. Combined antibiotics prove to be a relatively effective method to control such resistant strains. This study aim to investigate synergistic activity of eugenol combined with colistin against a collection of clinical isolated Escherichia coli (E.coli) strains, and to evaluate potential interaction. Antimicrobial susceptibility, minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) of the bacteria were determined by disk diffusion assay, broth microdilution method and checkerboard assay, respectively. The mcr-1 mRNA expression was measured by Real-time PCR. To predict possible interactions between eugenol and MCR-1, molecular docking assay was taken. For total fourteen strains including eight colistin-resistant strains, eugenol was determined with MIC values of 4 to 8 μg/mL. Checkerboard dilution test suggested that eugenol exhibited synergistic activity when combined with colistin (FICI ranging from 0.375 to 0.625). Comparison analysis of Real-time PCR showed that synergy could significantly down-regulate expression of mcr-1 gene. A metal ion coordination bond with catalytic zinc atom and a hydrogen bond with crucial amino acid residue Ser284 of MCR-1 were observed after molecular docking, indicating antibacterial activity and direct molecular interactions of eugenol with MCR-1 protein. Our results demonstrated that eugenol exhibited synergistic effect with colistin and enhanced its antimicrobial activity. This might further contribute to the antibacterial actions against colistin-resistant E.coli strains. Synergistic effect of eugenol with colistin against colistin-resistant Escherichia coli isolates.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 17%
Student > Bachelor 9 13%
Student > Ph. D. Student 7 10%
Researcher 6 9%
Student > Doctoral Student 3 4%
Other 10 14%
Unknown 22 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 10%
Agricultural and Biological Sciences 6 9%
Medicine and Dentistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Chemistry 4 6%
Other 13 19%
Unknown 28 41%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2018.
All research outputs
#14,965,143
of 23,018,998 outputs
Outputs from Antimicrobial Resistance and Infection Control
#988
of 1,288 outputs
Outputs of similar age
#256,498
of 441,593 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#38
of 46 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,288 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,593 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.

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