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Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis

Overview of attention for article published in Biotechnology for Biofuels, January 2018
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1 tweeter

Citations

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95 Mendeley
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Title
Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis
Published in
Biotechnology for Biofuels, January 2018
DOI 10.1186/s13068-018-1013-3
Pubmed ID
Authors

Gregorius Rionugroho Harvianto, Junaid Haider, Jimin Hong, Nguyen Van Duc Long, Jae-Jin Shim, Moo Hwan Cho, Woo Kyoung Kim, Moonyong Lee

Abstract

2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3-BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth. Conventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics. Oleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 20%
Student > Ph. D. Student 13 14%
Researcher 11 12%
Student > Bachelor 8 8%
Student > Doctoral Student 8 8%
Other 7 7%
Unknown 29 31%
Readers by discipline Count As %
Chemical Engineering 32 34%
Engineering 9 9%
Biochemistry, Genetics and Molecular Biology 6 6%
Agricultural and Biological Sciences 4 4%
Energy 2 2%
Other 5 5%
Unknown 37 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#7,804,382
of 12,439,436 outputs
Outputs from Biotechnology for Biofuels
#553
of 963 outputs
Outputs of similar age
#193,429
of 341,202 outputs
Outputs of similar age from Biotechnology for Biofuels
#10
of 21 outputs
Altmetric has tracked 12,439,436 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 963 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.