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Commensal microbiota modulate gene expression in the skin

Overview of attention for article published in Microbiome, January 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

blogs
1 blog
twitter
29 tweeters
facebook
2 Facebook pages

Citations

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93 Dimensions

Readers on

mendeley
183 Mendeley
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Title
Commensal microbiota modulate gene expression in the skin
Published in
Microbiome, January 2018
DOI 10.1186/s40168-018-0404-9
Pubmed ID
Authors

Jacquelyn S. Meisel, Georgia Sfyroera, Casey Bartow-McKenney, Ciara Gimblet, Julia Bugayev, Joseph Horwinski, Brian Kim, Jonathan R. Brestoff, Amanda S. Tyldsley, Qi Zheng, Brendan P. Hodkinson, David Artis, Elizabeth A. Grice

Abstract

The skin harbors complex communities of resident microorganisms, yet little is known of their physiological roles and the molecular mechanisms that mediate cutaneous host-microbe interactions. Here, we profiled skin transcriptomes of mice reared in the presence and absence of microbiota to elucidate the range of pathways and functions modulated in the skin by the microbiota. A total of 2820 genes were differentially regulated in response to microbial colonization and were enriched in gene ontology (GO) terms related to the host-immune response and epidermal differentiation. Innate immune response genes and genes involved in cytokine activity were generally upregulated in response to microbiota and included genes encoding toll-like receptors, antimicrobial peptides, the complement cascade, and genes involved in IL-1 family cytokine signaling and homing of T cells. Our results also reveal a role for the microbiota in modulating epidermal differentiation and development, with differential expression of genes in the epidermal differentiation complex (EDC). Genes with correlated co-expression patterns were enriched in binding sites for the transcription factors Klf4, AP-1, and SP-1, all implicated as regulators of epidermal differentiation. Finally, we identified transcriptional signatures of microbial regulation common to both the skin and the gastrointestinal tract. With this foundational approach, we establish a critical resource for understanding the genome-wide implications of microbially mediated gene expression in the skin and emphasize prospective ways in which the microbiome contributes to skin health and disease.

Twitter Demographics

The data shown below were collected from the profiles of 29 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 183 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 23%
Researcher 35 19%
Student > Bachelor 20 11%
Student > Master 16 9%
Other 12 7%
Other 26 14%
Unknown 32 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 20%
Immunology and Microbiology 35 19%
Biochemistry, Genetics and Molecular Biology 32 17%
Medicine and Dentistry 15 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 19 10%
Unknown 40 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2019.
All research outputs
#1,152,818
of 19,527,185 outputs
Outputs from Microbiome
#418
of 1,185 outputs
Outputs of similar age
#33,040
of 387,598 outputs
Outputs of similar age from Microbiome
#1
of 2 outputs
Altmetric has tracked 19,527,185 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,185 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.0. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,598 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them