BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. https://t.co/UAVmVsdDsR

Deletion of the gene GGA3 resulted in the accumulation of beta-amyloid in a mouse model through effects on the beta-secretase BACE1 https://t.co/6DTdRimpNh #Alzheimers affects trafficking of BACE1 to lysosomes for degradation suggests GGA3 depletion a m

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. https://t.co/ImiljhVv7X

RT @MolNeuro: BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL…