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The influence of gender on the effects of aspirin in preventing myocardial infarction

Overview of attention for article published in BMC Medicine, October 2007
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
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4 Wikipedia pages

Citations

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36 Dimensions

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84 Mendeley
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Title
The influence of gender on the effects of aspirin in preventing myocardial infarction
Published in
BMC Medicine, October 2007
DOI 10.1186/1741-7015-5-29
Pubmed ID
Authors

Todd Yerman, Wen Q Gan, Don D Sin

Abstract

There is considerable variation in the effect of aspirin therapy reducing the risk of myocardial infarction (MI). Gender could be a potential explanatory factor for the variability. We conducted a systematic review and meta-analysis to determine whether gender mix might play a role in explaining the large variation of aspirin efficacy across primary and secondary MI prevention trials. Randomized placebo-controlled clinical trials that examined the efficacy of aspirin therapy on MI were identified by using the PUBMED database (1966 to October 2006). Weighted linear regression technique was used to determine the relationship between log-transformed relative risk (RR) of MI and the percentage of male participants in each trial. The reciprocal of the standard error of the RR in each trial (1/SE) was used as the weight. A total of 23 trials (n = 113 494 participants) were identified. Overall, compared with placebo, aspirin reduced the risk of non-fatal MI (RR = 0.72, 95% confidence interval (CI) 0.64-0.81, p < 0.001) but not of fatal MI (RR = 0.88, 95% CI 0.75-1.03, p = 0.120). A total of 27% of the variation in the non-fatal MI results could be accounted for by considering the gender mix of the trials (p = 0.017). Trials that recruited predominantly men demonstrated the largest risk reduction in non-fatal MI (RR = 0.62, 95% CI 0.54-0.71), while trials that contained predominately women failed to demonstrate a significant risk reduction in non-fatal MI (RR = 0.87, 95% CI 0.71-1.06). Gender accounts for a substantial proportion of the variability in the efficacy of aspirin in reducing MI rates across these trials, and supports the notion that women might be less responsive to aspirin than men.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Norway 1 1%
Canada 1 1%
Brazil 1 1%
Unknown 81 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 15%
Student > Bachelor 13 15%
Researcher 8 10%
Professor 7 8%
Other 7 8%
Other 20 24%
Unknown 16 19%
Readers by discipline Count As %
Medicine and Dentistry 35 42%
Pharmacology, Toxicology and Pharmaceutical Science 8 10%
Agricultural and Biological Sciences 7 8%
Nursing and Health Professions 3 4%
Social Sciences 3 4%
Other 11 13%
Unknown 17 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2016.
All research outputs
#7,235,968
of 25,085,910 outputs
Outputs from BMC Medicine
#2,741
of 3,922 outputs
Outputs of similar age
#24,961
of 82,698 outputs
Outputs of similar age from BMC Medicine
#5
of 6 outputs
Altmetric has tracked 25,085,910 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,922 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.