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Reduction in HIV community viral loads following the implementation of a “Treatment as Prevention” strategy over 2 years at a population-level among men who have sex with men in Hangzhou, China

Overview of attention for article published in BMC Infectious Diseases, February 2018
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Title
Reduction in HIV community viral loads following the implementation of a “Treatment as Prevention” strategy over 2 years at a population-level among men who have sex with men in Hangzhou, China
Published in
BMC Infectious Diseases, February 2018
DOI 10.1186/s12879-017-2927-2
Pubmed ID
Authors

Lin He, Jiezhe Yang, Qiaoqin Ma, Jiafeng Zhang, Yun Xu, Yan Xia, Wanjun Chen, Hui Wang, Jinlei Zheng, Jun Jiang, Yan Luo, Ke Xu, Xingliang Zhang, Shichang Xia, Xiaohong Pan

Abstract

Previous studies have shown that the increased coverage of antiretroviral therapy (ART) could reduce the community viral load (CVL) and reduce the occurrence of new HIV infections. However, the impact on the reduction of HIV transmission among men who have sex with men (MSM) is much less certain. The frequency of HIV infections in MSM have been rapidly increasing in recent years in Hangzhou, China. The "Treatment as Prevention" strategy was implemented at a population-level for HIV-infected MSM from January 2014 to June 2016 in Hangzhou; it aimed to increase the ART coverage, reduce the CVL, and reduce HIV transmission. We investigated a subset of MSM diagnosed with HIV pre- and post-implementation of the strategy, using random sampling methods. Viral load (VL) testing was performed for all enrolled individuals; the lower limits of detection were 20 and 50 copies/mL. The data on infections were collected from the national epidemiology database of Hangzhou. Logistic regression analyses were conducted to identify factors associated with the differences in social demographic characteristics and available VL data. The ART coverage increased from 60.7% (839/1383) during the pre-implementation period to 92.3% (2183/2365) during the post-implementation period in Hangzhou. A total of 940 HIV-infected MSM were selected for inclusion in this study: 490 (52.1%) and 450 (47.9%) MSM in the pre- and post-implementation periods, respectively. In total, 89.5% (841/940) of patients had data available on VL rates. The mean CVL was 579 copies/mL pre-implementation and this decreased to 33 copies/mL post-implementation (Kruskal-Wallis < 0.001). The mean CVL decreased for all variables investigated post-implementation of the treatment strategy (P < 0.05). The undetectable VL (≤400 copies/mL) rate pre-implementation period was 50.0% which increased to 84.7% post-implementation (P < 0.001). The mean CVL at the county level significantly decreased in each county post-implementation (Kruskal-Wallis < 0.05). Our study confirmed a population-level association between increased ART coverage and decreased mean CVL; overall 84.7% of HIV infected MSM had an undetectable VL and were no longer infectious.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Student > Master 9 17%
Student > Ph. D. Student 5 9%
Other 3 6%
Student > Doctoral Student 3 6%
Other 6 11%
Unknown 19 35%
Readers by discipline Count As %
Medicine and Dentistry 16 30%
Nursing and Health Professions 7 13%
Biochemistry, Genetics and Molecular Biology 2 4%
Agricultural and Biological Sciences 2 4%
Veterinary Science and Veterinary Medicine 1 2%
Other 4 7%
Unknown 22 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2018.
All research outputs
#14,374,920
of 23,020,670 outputs
Outputs from BMC Infectious Diseases
#3,837
of 7,723 outputs
Outputs of similar age
#240,285
of 440,103 outputs
Outputs of similar age from BMC Infectious Diseases
#72
of 162 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,723 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,103 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.