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suPAR is associated with risk of future acute surgery and post-operative mortality in acutely admitted medical patients

Overview of attention for article published in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, February 2018
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  • Good Attention Score compared to outputs of the same age (65th percentile)

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4 tweeters

Citations

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10 Dimensions

Readers on

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26 Mendeley
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Title
suPAR is associated with risk of future acute surgery and post-operative mortality in acutely admitted medical patients
Published in
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, February 2018
DOI 10.1186/s13049-018-0478-1
Pubmed ID
Authors

Jeppe Meyer, Morten Alstrup, Line J. H. Rasmussen, Martin Schultz, Steen Ladelund, Thomas H. Haupt, Jens Tingleff, Kasper Iversen, Jesper Eugen-Olsen

Abstract

Acutely admitted medical patients are often fragile and in risk of future surgery. The biomarker soluble urokinase plasminogen activator receptor (suPAR) is a predictor of readmission and mortality in the acute care setting. We aimed to investigate if suPAR also predicts acute surgery, which is associated with higher mortality than elective surgery, and if it predicts post-operative mortality. A retrospective registry-based cohort study of 17,312 patients admitted to an acute medical unit in Denmark, from 18 November 2013 until 30 September 2015. The first admission with available suPAR was defined as the index admission, and patients were followed via national registries until 1 January 2016. The risk of acute surgery during the entire follow-up period as well as the 90-day post-operative mortality risk was modeled by Cox regression analyses adjusted for sex, age, C-reactive protein, and Charlson Comorbidity Index (Charlson Score). Acute surgery was carried out on 2404 patients (13.9%) after a median of 45 days (interquartile range 5-186) following the index admission. Patients receiving acute surgery had higher baseline suPAR compared with patients receiving elective- or no surgery (p < 0.0001). The hazard ratio (HR) for acute surgery was 1.50 (95% confidence interval (CI): 1.42-1.59) for every doubling of the suPAR level in the adjusted Cox regression analysis. Death within 90 days occurred in 439 (18.3%) patients receiving acute surgery, and the adjusted HR for post-operative mortality was 1.73 (95% CI: 1.52-1.95). Elevated levels of suPAR in acutely admitted medical patients were independently associated with increased risk of future acute surgery as well as with 90-day post-operative mortality. This retrospective registry-based cohort study was approved by the Danish Health and Medicines authority (reference no. 3-3013-1061/1). All processing of personal data followed national guidelines, and the project was approved by the Danish Data Protection Agency (reference no. HVH-2014-018, 02767).

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 15%
Student > Ph. D. Student 4 15%
Student > Postgraduate 3 12%
Student > Master 3 12%
Student > Bachelor 2 8%
Other 4 15%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 11 42%
Biochemistry, Genetics and Molecular Biology 3 12%
Unspecified 1 4%
Psychology 1 4%
Agricultural and Biological Sciences 1 4%
Other 2 8%
Unknown 7 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2018.
All research outputs
#4,052,933
of 14,030,622 outputs
Outputs from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#394
of 877 outputs
Outputs of similar age
#120,203
of 357,840 outputs
Outputs of similar age from Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#1
of 1 outputs
Altmetric has tracked 14,030,622 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 877 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them