Title |
Systematic review of influenza resistance to the neuraminidase inhibitors
|
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Published in |
BMC Infectious Diseases, May 2011
|
DOI | 10.1186/1471-2334-11-134 |
Pubmed ID | |
Authors |
Kristian Thorlund, Tahany Awad, Guy Boivin, Lehana Thabane |
Abstract |
Antivirals play a critical role in the prevention and the management of influenza. One class of antivirals, neuraminidase inhibitors (NAIs), is effective against all human influenza viruses. Currently there are two NAI drugs which are licensed worldwide: oseltamivir (Tamiflu®) and zanamivir (Relenza®); and two drugs which have received recent approval in Japan: peramivir and laninamivir. Until recently, the prevalence of antiviral resistance has been relatively low. However, almost all seasonal H1N1 strains that circulated in 2008-09 were resistant to oseltamivir whereas about 1% of tested 2009 pandemic H1N1 viruses were found to be resistant to oseltamivir. To date, no studies have demonstrated widespread resistance to zanamivir. It seems likely that the literature on antiviral resistance associated with oseltamivir as well as zanamivir is now sufficiently comprehensive to warrant a systematic review.The primary objectives were to systematically review the literature to determine the incidence of resistance to oseltamivir, zanamivir, and peramivir in different population groups as well as assess the clinical consequences of antiviral resistance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
Ireland | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
Unknown | 166 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 34 | 20% |
Student > Ph. D. Student | 18 | 11% |
Student > Master | 18 | 11% |
Student > Bachelor | 18 | 11% |
Other | 13 | 8% |
Other | 43 | 25% |
Unknown | 27 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 26% |
Agricultural and Biological Sciences | 37 | 22% |
Chemistry | 19 | 11% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
Other | 18 | 11% |
Unknown | 32 | 19% |