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Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate

Overview of attention for article published in EvoDevo, January 2018
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Title
Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate
Published in
EvoDevo, January 2018
DOI 10.1186/s13227-017-0090-x
Pubmed ID
Authors

Stanislav Kremnyov, Kristine Henningfeld, Christoph Viebahn, Nikoloz Tsikolia

Abstract

The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been attributed to sonic hedgehog (shh) signaling, which originates in the notochord, forms a gradient, and autoinduces shh expression in the floor plate. However, reported data are inconsistent and the spatiotemporal development of the relevant shh expression domains has not been studied in detail. We therefore studied the expression dynamics of shh in rabbit, chicken and Xenopus laevis embryos (as well as indian hedgehog and desert hedgehog as possible alternative functional candidates in the chicken). Our analysis reveals a markedly divergent pattern within these vertebrates: whereas in the rabbit shh is first expressed in the notochord and its floor plate domain is then induced during subsequent somitogenesis stages, in the chick embryo shh is expressed in the prospective neuroectoderm prior to the notochord formation and, interestingly, prior to mesoderm immigration. Neither indian hedgehog nor desert hedgehog are expressed in these midline structures although mRNA of both genes was detected in other structures of the early chick embryo. In X. laevis, shh is expressed at the beginning of gastrulation in a distinct area dorsal to the dorsal blastopore lip and adjacent to the prospective neuroectoderm, whereas the floor plate expresses shh at the end of gastrulation. While shh expression patterns in rabbit and X. laevis embryos are roughly compatible with the classical view of "ventral to dorsal induction" of the floor plate, the early shh expression in the chick floor plate challenges this model. Intriguingly, this alternative sequence of domain induction is related to the asymmetrical morphogenesis of the primitive node and other axial organs in the chick. Our results indicate that the floor plate in X. laevis and chick embryos may be initially induced by planar interaction within the ectoderm or epiblast. Furthermore, we propose that the mode of the floor plate induction adapts to the variant topography of interacting tissues during gastrulation and notochord formation and thereby reveals evolutionary plasticity of early embryonic induction.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 18%
Researcher 6 18%
Student > Master 6 18%
Student > Ph. D. Student 5 15%
Lecturer 2 6%
Other 3 9%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 45%
Agricultural and Biological Sciences 10 30%
Neuroscience 3 9%
Unknown 5 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2018.
All research outputs
#17,930,799
of 23,023,224 outputs
Outputs from EvoDevo
#284
of 320 outputs
Outputs of similar age
#309,648
of 440,208 outputs
Outputs of similar age from EvoDevo
#7
of 7 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 320 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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