Title |
Defining functional distances over Gene Ontology
|
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Published in |
BMC Bioinformatics, January 2008
|
DOI | 10.1186/1471-2105-9-50 |
Pubmed ID | |
Authors |
Angela del Pozo, Florencio Pazos, Alfonso Valencia |
Abstract |
A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-structured ontologies exist regarding the activity of proteins (i.e. 'gene ontology' -GO-). However, functional metrics can overcome the problems in the comparing and evaluating functional assignments and predictions. As a reference of proximity, previous approaches to compare GO terms considered linkage in terms of ontology weighted by a probability distribution that balances the non-uniform 'richness' of different parts of the Direct Acyclic Graph. Here, we have followed a different approach to quantify functional similarities between GO terms. |
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