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Osteogenic potential of osteoblasts from neonatal rats born to mothers treated with caffeine throughout pregnancy

Overview of attention for article published in BMC Musculoskeletal Disorders, February 2015
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Title
Osteogenic potential of osteoblasts from neonatal rats born to mothers treated with caffeine throughout pregnancy
Published in
BMC Musculoskeletal Disorders, February 2015
DOI 10.1186/s12891-015-0467-8
Pubmed ID
Authors

Amanda Maria Sena Reis, Lorena Gabriela Rocha Ribeiro, Natália de Melo Ocarino, Alfredo Miranda Goes, Rogéria Serakides

Abstract

BackgroundCaffeine is an active alkaloid that can cause damage to bones in formation during prenatal life into adulthood. This compound can pass across the placenta and into the mother¿s milk, causing a reduction in bone formation, growth and mass. The objective of this study was to examine the osteogenic potential of osteoblasts extracted from neonatal rats born to mothers treated with caffeine throughout pregnancy.MethodsTwenty-four adult Wistar rats were randomly divided into four groups, consisting of one control group and three groups that were treated with 25, 50, or 100 mg/kg of caffeine by an oral-gastric probe throughout the duration of the experimental period (pregnancy). At birth, three puppies from each dam in each group were euthanized, and osteoblasts were extracted from the calvaria of these pups for in vitro testing.ResultsThe osteoblasts extracted from the pups of rats that received 50 mg/kg caffeine during pregnancy exhibited increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen transcripts, resulting in increased synthesis of mineralization nodules.ConclusionsNeonates from rats treated with 50 mg/kg caffeine during pregnancy contained osteoblasts with a higher osteogenic potential characterized by increased expression of osteocalcin, osteopontin, sialoprotein, runx-2, alkaline phosphatase and type I collagen and increased synthesis of mineralization nodules.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 21%
Researcher 6 16%
Student > Master 5 13%
Other 3 8%
Student > Doctoral Student 2 5%
Other 7 18%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 11 29%
Biochemistry, Genetics and Molecular Biology 4 11%
Agricultural and Biological Sciences 3 8%
Veterinary Science and Veterinary Medicine 2 5%
Unspecified 2 5%
Other 6 16%
Unknown 10 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2015.
All research outputs
#15,557,505
of 23,881,329 outputs
Outputs from BMC Musculoskeletal Disorders
#2,417
of 4,185 outputs
Outputs of similar age
#204,555
of 357,214 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#29
of 51 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,185 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,214 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.