↓ Skip to main content

The clinical efficacy of artemether/lumefantrine (Coartem®)

Overview of attention for article published in Malaria Journal, October 2009
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

blogs
1 blog
wikipedia
9 Wikipedia pages

Citations

dimensions_citation
79 Dimensions

Readers on

mendeley
173 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The clinical efficacy of artemether/lumefantrine (Coartem®)
Published in
Malaria Journal, October 2009
DOI 10.1186/1475-2875-8-s1-s5
Pubmed ID
Authors

Michael Makanga, Srivicha Krudsood

Abstract

Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT prequalified by the WHO for efficacy, safety and quality, approved by Swissmedic in December 2008 and recently approved by the USA FDA. Coartem is a fixed-dose combination of artemether and lumefantrine. Its two components have different modes of action that provide synergistic anti-malarial activity. It is indicated for the treatment of infants, children and adults with acute, uncomplicated infection due to Plasmodium falciparum or mixed infections including P. falciparum. A formulation with improved palatability has been developed especially for children (Coartem Dispersible), which rapidly disperses in a small amount of water for ease of administration. The efficacy of the six-dose regimen of artemether/lumefantrine has been confirmed in many different patient populations around the world, consistently achieving 28-day PCR (polymerase chain reaction)-corrected cure rates of >95% in the evaluable population, rapidly clearing parasitaemia and fever, and demonstrating a significant gametocidal effect, even in areas of widespread parasite resistance to other antimalarials.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Switzerland 1 <1%
Tanzania, United Republic of 1 <1%
Vietnam 1 <1%
Mali 1 <1%
Kenya 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Belgium 1 <1%
Other 0 0%
Unknown 164 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 31 18%
Student > Ph. D. Student 20 12%
Student > Bachelor 19 11%
Researcher 18 10%
Other 12 7%
Other 29 17%
Unknown 44 25%
Readers by discipline Count As %
Medicine and Dentistry 42 24%
Pharmacology, Toxicology and Pharmaceutical Science 23 13%
Agricultural and Biological Sciences 23 13%
Biochemistry, Genetics and Molecular Biology 10 6%
Immunology and Microbiology 5 3%
Other 21 12%
Unknown 49 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2023.
All research outputs
#3,789,028
of 23,072,295 outputs
Outputs from Malaria Journal
#903
of 5,612 outputs
Outputs of similar age
#14,978
of 94,133 outputs
Outputs of similar age from Malaria Journal
#5
of 42 outputs
Altmetric has tracked 23,072,295 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,612 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.