Title |
Pros and cons of CLA consumption: an insight from clinical evidences
|
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Published in |
Nutrition & Metabolism, February 2015
|
DOI | 10.1186/1743-7075-12-4 |
Pubmed ID | |
Authors |
Sailas Benjamin, Priji Prakasan, Sajith Sreedharan, Andre-Denis G Wright, Friedrich Spener |
Abstract |
This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 27% |
Poland | 1 | 9% |
Germany | 1 | 9% |
France | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 82% |
Scientists | 1 | 9% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Chile | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 206 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 33 | 16% |
Researcher | 29 | 14% |
Student > Bachelor | 28 | 13% |
Student > Ph. D. Student | 24 | 11% |
Student > Doctoral Student | 14 | 7% |
Other | 35 | 17% |
Unknown | 46 | 22% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 38 | 18% |
Medicine and Dentistry | 30 | 14% |
Nursing and Health Professions | 18 | 9% |
Biochemistry, Genetics and Molecular Biology | 16 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Other | 39 | 19% |
Unknown | 60 | 29% |