You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hypoxia following etorphine administration in goats (Capra hircus) results more from pulmonary hypertension than from hypoventilation
|
|---|---|
| Published in |
BMC Veterinary Research, February 2015
|
| DOI | 10.1186/s12917-015-0337-5 |
| Pubmed ID | |
| Authors |
Leith Carl Rodney Meyer, Robyn Sheila Hetem, Duncan Mitchell, Andrea Fuller |
| Abstract |
BackgroundEtorphine, a potent opioid agonist, causes pulmonary hypertension and respiratory depression. Whether etorphine-induced pulmonary hypertension negatively influences pulmonary gas exchange and exacerbates the effects of ventilator depression and the resultant hypoxemia is unknown. To determine if these effects occurred we instrumented twelve goats with peripheral and pulmonary arterial catheters to measure systemic and pulmonary pressures before and after etorphine administration. Concurrent cardiopulmonary and arterial blood gas variables were also measured.ResultsEtorphine induced hypoventilation (55% reduction to 7.6¿±¿2.7 L.min¿1, F(11,44)¿=¿15.2 P¿<¿0.0001), hypoxia (<45 mmHg, F(11,44)¿=¿8.6 P¿<¿0.0001), hypercapnia (>40 mmHg, F(11,44)¿=¿5.6 P¿<¿0.0001) and pulmonary hypertension (mean 23¿±¿6 mmHg, F(11,44)¿=¿8.2 P¿<¿0.0001). Within 6 min of etorphine administration hypoxia was twice (F(11,22)¿=¿3.0 P¿<¿0.05) as poor than that expected from etorphine-induced hypoventilation alone. This disparity appeared to result from a decrease in the movement of oxygen (gas exchange) across the alveoli membrane, as revealed by an increase in the P(A-a)O2 gradient (F(11,44)¿=¿7.9 P¿<¿0.0001). The P(A-a)O2 gradient was not correlated with global changes in the ventilation perfusion ratio (P¿=¿0.28) but was correlated positively with the mean pulmonary artery pressure (P¿=¿0.017, r2¿=¿0.97), indicating that pulmonary pressure played a significant role in altering pulmonary gas exchange.ConclusionAttempts to alleviate etorphine-induced hypoxia therefore should focus not only on reversing the opioid-induced respiratory depression, but also on improving gas exchange by preventing etorphine-induced pulmonary hypertension. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 17% |
| Student > Doctoral Student | 4 | 11% |
| Researcher | 3 | 8% |
| Other | 3 | 8% |
| Student > Bachelor | 2 | 6% |
| Other | 8 | 22% |
| Unknown | 10 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 7 | 19% |
| Medicine and Dentistry | 7 | 19% |
| Agricultural and Biological Sciences | 4 | 11% |
| Neuroscience | 2 | 6% |
| Computer Science | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 12 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2021.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from BMC Veterinary Research
#1,112
of 3,298 outputs
Outputs of similar age
#195,280
of 360,623 outputs
Outputs of similar age from BMC Veterinary Research
#27
of 61 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,298 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,623 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.