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Impairment of social behaviors in Arhgef10 knockout mice

Overview of attention for article published in Molecular Autism, February 2018
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  • Good Attention Score compared to outputs of the same age (71st percentile)

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4 X users
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1 Wikipedia page

Citations

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23 Dimensions

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59 Mendeley
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Title
Impairment of social behaviors in Arhgef10 knockout mice
Published in
Molecular Autism, February 2018
DOI 10.1186/s13229-018-0197-5
Pubmed ID
Authors

Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau, Wen-Mei Fu

Abstract

Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region isARHGEF10. A missense mutation ofARHGEF10has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear. We generatedArhgef10knockout mice as a model of ASD and characterized the social behavior and the biochemical changes in the brains of the knockout mice. Compared with their wild-type littermates, theArhgef10-depleted mice showed social interaction impairment, hyperactivity, and decreased depression-like and anxiety-like behavior. Behavioral measures of learning in the Morris water maze were not affected byArhgef10deficiency. Moreover, neurotransmitters including serotonin, norepinephrine, and dopamine were significantly increased in different brain regions of theArhgef10knockout mice. In addition, monoamine oxidase A (MAO-A) decreased in several brain regions. These results suggest thatARHGEF10is a candidate risk gene for ASD and that theArhgef10knockout model could be a tool for studying the mechanisms of neurotransmission in ASD. Animal studies were approved by the Institutional Animal Care and Use Committee of National Taiwan University (IACUC 20150023). Registered 1 August 2015.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 15%
Researcher 7 12%
Student > Master 7 12%
Student > Bachelor 3 5%
Student > Doctoral Student 3 5%
Other 10 17%
Unknown 20 34%
Readers by discipline Count As %
Psychology 10 17%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Neuroscience 5 8%
Biochemistry, Genetics and Molecular Biology 4 7%
Nursing and Health Professions 3 5%
Other 9 15%
Unknown 23 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2018.
All research outputs
#6,063,541
of 23,023,224 outputs
Outputs from Molecular Autism
#416
of 672 outputs
Outputs of similar age
#126,588
of 446,078 outputs
Outputs of similar age from Molecular Autism
#16
of 21 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 672 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.