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Comparison of hepatitis E virus seroprevalence between HBsAg-positive population and healthy controls in Shandong province, China

Overview of attention for article published in BMC Infectious Diseases, February 2018
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Title
Comparison of hepatitis E virus seroprevalence between HBsAg-positive population and healthy controls in Shandong province, China
Published in
BMC Infectious Diseases, February 2018
DOI 10.1186/s12879-018-2974-3
Pubmed ID
Authors

Li Zhang, Zechun Jiang, Jingjing Lv, Jiaye Liu, Bingyu Yan, Yi Feng, Li Li, Guomin Zhang, Fuzhen Wang, Aiqiang Xu

Abstract

Persons with chronic hepatitis B (CHB) infection were reported to suffer severe disease after hepatitis E virus (HEV) superinfection, but the studies regarding HEV seroprevalence in this population were limited. A recent study in Vietnam found higher HEV seroprevalence among CHB patients compared with healthy controls. A community-based case-control study was conducted in two counties of Shandong province, China, where hepatitis E incidence was at the highest (Rushan) and lowest (Zhangqiu) in the province based on data from routine public health surveillance. Four townships were selected randomly from each county and all residents in these townships were tested for hepatitis B surface antigen (HBsAg). Those tested positive for HBsAg (CHB group) and the 1:1 age and sex-matched HBsAg-negative residents (control group) were included. Anti-HEV IgM and IgG were tested and positive rates of IgG and IgM were compared between the CHB group and the control group. In total, 2048 CHB participants and 2054 controls were included in the study. In the CHB group, HEV IgG seroprevalence was 9.16% (95% CI: 7.47-11.09) in Zhangqiue and 38.06% (95% CI: 35.07-41.19) in Rushan (P < 0.001); the corresponding rates of IgM were 0.1% (95% CI: 0.002-0.54) and 1.57% (95% CI: 0.90-2.53), respectively (P < 0.001). HEV IgG seroprevalence was similar between CHB group and the control group in both counties (P = 0.21, P = 0.47, respectively) and the same results were found for the positive rate of IgM (P = 0.103, P = 0.262, respectively). Multivariable analysis showed the status of HBsAg was not independently associated with the status of anti-HEV IgG in either Zhangqiu or Rushan [P = 0.187, OR = 1.23(95% CI: 0.90, 1.68); P = 0.609, OR = 1.05 (95% CI: 0.87, 1.26)]. The seroprevalence of HEV varies greatly in different geographic areas, but the seroprevalence is similar between populations with and without CHB. CHB patients residing in high HEV endemic areas might be at higher risk for HBV-HEV superinfection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 23%
Student > Master 4 15%
Student > Postgraduate 2 8%
Lecturer 1 4%
Student > Bachelor 1 4%
Other 3 12%
Unknown 9 35%
Readers by discipline Count As %
Medicine and Dentistry 7 27%
Social Sciences 3 12%
Immunology and Microbiology 2 8%
Psychology 1 4%
Environmental Science 1 4%
Other 2 8%
Unknown 10 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2018.
All research outputs
#17,930,799
of 23,023,224 outputs
Outputs from BMC Infectious Diseases
#5,165
of 7,724 outputs
Outputs of similar age
#313,853
of 445,207 outputs
Outputs of similar age from BMC Infectious Diseases
#83
of 141 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,724 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,207 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.