Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration https://t.co/c1RTwgTjaR #parkinson #genetic #LRRK2 #neurology #brain
462 followers
687 followers
RT @ScienceofPD: A screening study revealed that Rab GTPases are authentic substrates of #Parkinsons-associated LRRK2, particularly Rab35.…
10,274 followers
A screening study revealed that Rab GTPases are authentic substrates of #Parkinsons-associated LRRK2, particularly Rab35. Mutating LRRK2 sites on Rab35 induces neurotoxicity, suggesting that Rab GTPases might mediate LRRK2 toxicity in the progression of PD
565 followers
Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration. https://t.co/fauongN2Cp #Neuralstemcells